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Mitosis and Cell Cycle worksheet - Free Printable

Mitosis and Cell Cycle worksheet

Educational worksheet: Mitosis and Cell Cycle worksheet. Download and print for classroom or home learning activities.

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Here is the complete solution to your mitosis worksheet, with clear explanations for each answer.

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Label the phases of Mitosis below:



11. Interphase
*Explanation:* The cell has a visible nucleus and nucleolus, chromatin is uncondensed, and centrosomes are present but not yet forming spindle fibers. This is the preparatory phase before mitosis begins.

12. Metaphase
*Explanation:* Chromosomes are aligned at the equator (metaphase plate) of the cell, attached to spindle fibers from opposite poles.

13. Anaphase
*Explanation:* Sister chromatids have separated and are being pulled toward opposite poles of the cell by spindle fibers.

14. Telophase
*Explanation:* Chromosomes are arriving at the poles, nuclear envelopes are reforming around each set, and the cell is beginning to pinch inward (cleavage furrow in animal cells).

15. Cytokinesis (or Post-Telophase)
*Explanation:* Two distinct daughter cells are forming, each with its own nucleus. The cytoplasm is divided. In animal cells, this is shown by the cleavage furrow fully pinching the cell apart.

> *Note: While technically cytokinesis is not part of mitosis (which is nuclear division), it often follows telophase and is included in diagrams as the final step of cell division.*

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Complete the table by selecting yes and no:



| Statement | Interphase | Mitosis |
|------------------------------------------------|----------|---------|
| 16. Cell growth occurs | Yes | No |
| 17. Nuclear division occurs | No | Yes |
| 18. Chromosomes are finishing moving into separate daughter cells. | No | Yes |
| 19. Chromosomes are duplicated | Yes | No |
| 20. DNA synthesis occurs | Yes | No |
| 21. Where cells spend most of their life | Yes | No |
| 22. Mitochondria and other organelles are made | Yes | No |

Explanations:

- Interphase is the longest phase — cells grow, replicate DNA (S phase), synthesize proteins/organelles, and prepare for division.
- Mitosis is the actual division phase — chromosomes condense, align, separate, and nuclei reform. No growth or DNA synthesis occurs here.
- Statement 18: Refers to telophase/cytokinesis — chromosomes are completing their movement to opposite poles.
- Statement 19 & 20: Chromosome duplication = DNA replication → happens in S phase of interphase.
- Statement 21: Cells spend ~90% of their time in interphase.
- Statement 22: Organelle production occurs during G1 and G2 phases of interphase.

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Use the following illustrations for questions 23–32



*(Assuming standard mitosis labeling: D = Interphase, A = Prophase, F = Metaphase, C = Metaphase (side view), E = Anaphase, B = Telophase)*

23. In cell A, what is the structure labeled X?
Spindle fiber (or microtubule)
*Explanation:* In prophase, spindle fibers begin forming from centrosomes and attach to chromosomes.

24. In cell F, what is the structure labeled Y?
Chromosome (or sister chromatid pair)
*Explanation:* In metaphase, chromosomes are aligned at the equator. Y points to one chromosome composed of two sister chromatids.

25. Which cell is not in a phase of mitosis?
D
*Explanation:* Cell D shows an intact nucleus with diffuse chromatin — this is interphase, not mitosis.

26. New nuclear membranes are forming in B. What is this phase called?
Telophase
*Explanation:* Telophase is characterized by reformation of nuclear envelopes around separated chromosomes.

27. Sequence the six diagrams in chronological order from first to last.
D → A → F → C → E → B
*Explanation:*
- D: Interphase (start)
- A: Prophase (chromosomes condense, spindle forms)
- F: Metaphase (chromosomes align)
- C: Metaphase (same as F, different angle — can be interchangeable)
- E: Anaphase (sister chromatids separate)
- B: Telophase (nuclear membranes reform)

> *Note: F and C both show metaphase; either can come after A. But since F is clearly showing alignment, and C is another view, we’ll put F then C for flow.*

28. Chromosomes move to the middle of the cell during?
Metaphase
*Explanation:* Spindle fibers pull chromosomes to the metaphase plate (equator).

29. When do the sister chromatids separate?
Anaphase
*Explanation:* The centromeres split, and spindle fibers pull chromatids apart to opposite poles.

30. During which phase do chromosomes first become visible?
Prophase
*Explanation:* Chromatin condenses into visible chromosomes during prophase.

31. During which phase does the cleavage furrow start forming on animal cells?
Telophase
*Explanation:* Cleavage furrow begins to form during telophase as cytokinesis starts, pinching the cell membrane inward.

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Final Answer Summary:

Phase Labels:
11. Interphase
12. Metaphase
13. Anaphase
14. Telophase
15. Cytokinesis

Table Answers:
16. Interphase
17. Mitosis
18. Mitosis
19. Interphase
20. Interphase
21. Interphase
22. Interphase

Questions 23–31:
23. Spindle fiber
24. Chromosome (or sister chromatid pair)
25. D
26. Telophase
27. D → A → F → C → E → B
28. Metaphase
29. Anaphase
30. Prophase
31. Telophase

Let me know if you’d like a diagram explanation or flashcards for memorization!
Parent Tip: Review the logic above to help your child master the concept of cell division and mitosis worksheet.
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