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Free Printable Mutations Worksheet with Answer Keys - Free Printable

Educational worksheet: Free Printable Mutations Worksheet with Answer Keys. Download and print for classroom or home learning activities.

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- a. Normal: mRNA: CCC GAA GAA AAA; Normal Amino Acid: PRO GLU GLU LYS. Sickle: mRNA: CCC GUA GAA AAA; Sickle Amino Acid: PRO VAL GLU LYS.
- b. It is a point mutation of the missense kind: a single base substitution in the normal DNA (CTT to CAT) caused a different amino acid (GLU to VAL) to be added.
- c. mRNA: CCC GAA GAA UUU; Amino Acid: PRO GLU GLU PHE. No, this would not result in sickle cell hemoglobin because the mutation changes the last amino acid from LYS to PHE, not from GLU to VAL at the second position, which is the defining change for sickle cell disease.

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