Mutations Worksheet covering deletion, insertion, and substitution mutations with DNA sequences and analysis questions.

- Original DNA Sequence: T A C A C C T T G G C G A C G A C T
- mRNA Sequence: A U G U G G A A C C G C U G C U G A
- Amino Acid Sequence: Met - Trp - Asn - Arg - Cys - Stop

- Mutated DNA Sequence #1: T A C A T C T T G G C G A C G A C T
- mRNA Sequence: A U G U A G A A C C G C U G C U G A (Circle the change: UAG)
- Amino Acid Sequence: Met - Stop
- Will there likely be effects? Yes
- What kind of mutation is this? Nonsense

- Mutated DNA Sequence #2: T A C G A C C T T G G C G A C G A C T
- mRNA Sequence: A U G C U G G A A C C G C U G C U G A (Circle the change: CUG)
- Amino Acid Sequence: Met - Leu - Glu - Pro - Leu - Leu
- Will there likely be effects? Yes
- What kind of mutation is this? Missense

- Mutated DNA Sequence #3: T A C A C C T T A G C G A C G A C T
- mRNA Sequence: A U G U G G A A U C G C U G C U G A (Circle the change: AAU)
- Amino Acid Sequence: Met - Trp - Asn - Arg - Cys - Stop
- Will there likely be effects? No
- What kind of mutation is this? Silent

- Mutated DNA Sequence #4: T A C A C C T T G G C G A C T A C T
- mRNA Sequence: A U G U G G A A C C G C U G A U G A (Circle the change: UGA)
- Amino Acid Sequence: Met - Trp - Asn - Arg - Stop
- Will there likely be effects? Yes
- What kind of mutation is this? Nonsense