- Original DNA sequence: TAC ACC TTG GCG ACG ACT
- mRNA transcript: AUG UGG AAC CGC UGC UGA
- amino acids: Met-Trp-Asn-Arg-Cys-Stop
- Mutated DNA sequence #1: TAC ATC TTG GCG ACG ACT
- mRNA transcript: AUG UAG AAC CGC UGC UGA
- amino acids: Met-Stop
- Type of mutation: Point → Substitution
- How did the mutation affect the amino acid sequence (protein)?: Premature stop signal
- Mutated DNA sequence #2: TAC GAC CTT GGC GAC GAC T
- mRNA transcript: AUG CUG GAA CCG CUG CUG A
- amino acids: Met-Leu-Glu-Pro-Leu-Leu
- Type of mutation: Frameshift → Insertion
- How did the mutation affect the amino acid sequence (protein)?: All the amino acids changed after the point of mutation
- Mutated DNA sequence #3: TAC ACC TTA GCG ACG ACT
- mRNA transcript: AUG UGG AAU CGC UGC UGA
- amino acids: Met-Trp-Asn-Arg-Cys-Stop
- Type of mutation: Point → Substitution
- How did the mutation affect the amino acid sequence (protein)?: No change
Parent Tip: Review the logic above to help your child master the concept of genetic mutation worksheet.
