Sickle cell hemoglobin mutation analysis using codon table and DNA sequences.

A biology worksheet showing a codon table and a question about the genetic mutation causing sickle cell hemoglobin, with sequences for normal and sickle cell hemoglobin and their translations.

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Show Answer Key & Explanations Step-by-step solution for: Worksheet: Mutations Practice Worksheet

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- a. Transcribe and translate the normal and sickle cell DNA.
- normal: mRNA: CCC GAA GAA AAA; normal Amino Acid: PRO GLU GLU LYS
- sickle: mRNA: CCC GUA GAA AAA; sickle amino acid: PRO VAL GLU LYS

- b. Identify this as a point or frameshift mutation. Explain.
- It is a point mutation of the missense kind: a single base substitution in the normal DNA caused a different amino acid to be added.

- c. If the base sequence read GGG CTT CTT AAA instead, would this result in sickle cell hemoglobin? Explain.
- mRNA: CCC GAA GAA UUU; Amino Acid: PRO GLU GLU PHE
- No. The "normal" amino acid "LYS" got replaced by "PHE", which is not the valine (VAL) substitution characteristic of sickle cell hemoglobin.

Parent Tip: Review the logic above to help your child master the concept of mutations practice worksheet.

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