Mitosis Worksheet | PDF - Free Printable

Let’s go step by step through each question.

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Question 1: Chromosomes move to the middle of the spindle during what phase?

Looking at the diagram:
- In Metaphase, chromosomes are lined up in the center (middle) of the cell, attached to spindle fibers from both sides.
→ So the answer is Metaphase.

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Question 2: What are sister chromatids? When do the sister chromatids separate?

Sister chromatids are two identical copies of a chromosome that are joined together at the centromere. They form when DNA replicates during interphase.

They separate during Anaphase — that’s when the spindle pulls them apart to opposite ends of the cell.

→ Answer:
*Sister chromatids are identical copies of a chromosome, joined at the centromere. They separate during Anaphase.*

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Question 3: During which phase do chromosomes first become visible?

In Interphase, chromosomes are loose and not visible under a microscope.
In Prophase, they condense and become visible as distinct structures.

→ Answer: Prophase

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Question 4: In multicellular organisms, the cell cycle produces groups of cells that perform the same function. What are these groups of cells called?

Groups of similar cells working together = tissues

→ Answer: Tissues

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Now for the table: We check whether each statement happens in Interphase or Mitosis.

Remember:
- Interphase: Cell grows, makes proteins, duplicates DNA/organelles → prepares for division.
- Mitosis: Actual division of nucleus and cytoplasm → splits into two daughter cells.

Let’s go one by one:

5. Cell growth occurs → Happens in Interphase (G1 and G2 phases).
✔ Interphase

6. Nuclear division occurs → That’s Mitosis (prophase to telophase).
✔ Mitosis

7. Chromosomes are distributed equally to daughter cells. → This happens during mitosis (anaphase/telophase).
✔ Mitosis

8. Protein production is high → Cells make lots of proteins during interphase to grow and prepare.
✔ Interphase

9. Chromosomes are duplicated → Happens in S phase of Interphase.
✔ Interphase

10. DNA synthesis occurs → Also S phase of Interphase.
✔ Interphase

11. Cytoplasm divides immediately after this period → After mitosis comes cytokinesis (cytoplasm division). So “this period” = Mitosis.
✔ Mitosis

12. Mitochondria and other organelles are made. → Happens during interphase (especially G1 and G2).
✔ Interphase

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Final Answers:

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Final Answer:
1. Metaphase
2. Sister chromatids are identical copies of a chromosome joined at the centromere; they separate during Anaphase.
3. Prophase
4. Tissues

Table:
5. Interphase
6. Mitosis
7. Mitosis
8. Interphase
9. Interphase
10. Interphase
11. Mitosis
12. Interphase